On the eve of her 19th birthday, Nina finds out that she has been cursed since ancient Roman times by Emperor Justinian. She carries a plague that can wipe out the human race. The Book of Fire reveals that Nina can choose to live and infect millions, or avoid the fate by spending eternity in purgatory. She has three days to decide, and so Nina has no choice but to make her own destiny.
All the couples are back for a wedding in Las Vegas, but plans for a romantic weekend go awry when their various misadventures get them into some compromising situations that threaten to derail the big event.
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