Mio is a girl in high school who slacks off. She and her childhood friend Arata and best friend Madoka spend their after-school days in Ikebukuro hanging out. One day, Madoka tells Mio that she loves Arata, and Mio realizes that she loves Arata, too. But she’s scared of their relationship falling apart and lies, saying she’ll help them. Mio deliberately acts coldly to Arata, and they get into a fight. She decides to work things out with Arata, but gets into a car accident on her way to meet him. She wakes up in a mysterious world. It's the Ikebukuro she knows, but something’s different...
Yuri Rintaro used to work as the chief of the First Investigation Division in Tokyo. Due to a case, he resigned from the police force and moved back to his hometown of Kyoto. Now, he works as a forensic psychologist in Kyoto. After receiving requests from the police, he helps them with their investigations. His investigation method involves careful observance of the crime scenes and he uses trace techniques learned from a hunter. He met that hunter in the Rocky Mountains, USA, during his school days. His assistant in Kyoto is Mitsugi Shunsuke. Mitsugi admires Yuri and runs the website "Yuri Rintaro no Jikenbo," which records Yuri's performance.
A woman was killed by a truck wheel, which flew off while the vehicle was in motion. As the freight company which owns the truck becomes the target of the public and the media’s wrath, Tokuro Akamatsu, the president of the freight company, realizes that a structural defect within the truck itself may have been to blame. A conspiracy of the wheel manufacturer's attempts to cover up a defective product is uncovered.
University student Wakamizu Ryota (Emoto Tokio), who is the middle of job hunting, gets caught up in a sudden gang dispute. Ryota’s life is saved by Yanagiba Ryuichi (Namase Katsuhisa), the boss of Yanagiba-gumi, and Ryota for some reason ends up harbouring Yanagiba in his own home. Ignoring Ryota who wants him to leave immediately, Yanagiba uses the leftover food in the fridge and starts to prepare a meal without asking. However, the meal is surprisingly delicious despite the leftovers that did not seem possible to combine. This is the beginning of a bizarre communal life connected by meals for a gangster and a university student.
When this happens though, she blacks out. Even in her day-to-day life, she can hear people's evil intentions and true colors and senses their lies and deception. That is why she always wears headphones in order to shut out people's emotions. She works well with her colleagues at the "Red Spider Lily" (Higanbana) unit, who are all brutally honest acid-tongued women with no qualms about speaking their minds. "Red Spider Lily" is an eclectic unit that includes a science geek, a single mom, and a woman who grew up abroad. Seen by many as a department that's been taken off the main career track, "Red Spider Lily" turns out to be full of fabulous detectives!
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